What is the preferred concentration of epinephrine for IV or intraosseous administration in neonates?

The preferred concentration of epinephrine for intravenous (IV) or intraosseous administration in neonates is 1:10,000. This concentration is specifically formulated for pediatric use, including neonates, because it allows for effective management of severe bradycardia or cardiac arrest in this vulnerable population.

Using the 1:10,000 concentration ensures that the dose is safe and effective, considering the lower body weight and unique physiological responses of neonates compared to older patients. In cases of resuscitation, timely and appropriate dosing can significantly impact outcomes, making it crucial to have the correct concentration readily available during neonatal emergencies.

In contrast, other concentrations such as 1:1,000 or 1:1 are not appropriate for IV or intraosseous administration in this age group due to the risk of cardiovascular complications from overdose. The concentration of 1:100,000 is generally used for different clinical scenarios, such as for topical applications or specific emergency settings, rather than for direct IV administration during resuscitation.